New tablets against diabetes are ready to make a real revolution in medicine
As Health Day notes the injectable diabetic medicine - glucagon-like peptide-1 (GLP-1) - may be released in the form of tablets. Experimental tablets have already been tested on volunteers. More than 1100 people with type 2 diabetes participated in the trials lasting 26 weeks. People were divided into several groups. In the one group, 1 mg Semaglutide injections were performed weekly. Five other groups were given different dosages orally - 2.5, 5, 10, 20 or 40 mg. Another group was given an oral dosage form of the drug with a constant increase in dosage. There was also a placebo group.
The highest oral dose of the drug worked as effectively as the injection. It well-regulated the blood sugar concentrations and allowed to reduce the volunteer’s weight. On average, glycated hemoglobin levels (blood sugar) have decreased by 1.9% in people who took 40 mg of the drug. More than 70% of volunteers lost the body weight by at least 5% (about 6.8 kg).
According to Dr. Robert Corgi, an american endocrinologist, the oral drug is able to change people's lives significantly. Semaglutide is effective, but a lot of people do not want injections. The tablet is another story. By the way, earlier it was proved that the injection also reduces the death rate from cardiovascular ailments.
Source: Health Day