Scientists have revealed a way for slowing down the brain "aging"
American scientists from Columbia University have found that the hormone osteocalcin can be a “cure” for the brain aging. The researchers noted that osteocalcin is produced by bone tissue cells and even small physical activity contributes to its activation.
New data promotes the further study of the molecular mechanism underlying the memory formation, and searching for ways to effectively influence on its activity. The study also gives a clearer idea of how lifestyle changes, in this case, increased physical activity, can positively influence on the aging brain.
The study was carried out by a group of scientists led by Nobel Prize winner Eric Richard Kandel.
Upon completion of the research, it became clear that RbAp48 protein, which prevents the onset of senile dementia, interacts with osteocalcin. The scientists have demonstrated that RbAp48 interacts with osteocalcin. RbAp48 controls the activity of genes encoding BDNF neurotrophic factor of the brain and GPR158 protein receptor.
The full performance of these compounds depends on osteocalcin concentration.
Even a small physical activity, such as walking, helps to release osteocalcin and RbAp48, as a result the risk of developing senile dementia reduces.
At the same time, the scientists noted that thanks to the study, they were able to discover new fundamental differences between age-related memory loss and Alzheimer's disease.
“The revealed complex sequence of molecular signals is completely different from those associated with Alzheimer's disease. This is the most vivid evidence that age-related memory loss and Alzheimer's are completely different diseases” said Dr. E.R. Kandel